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1 article(s) from Fu, ZiYi

Efficient synthesis of piperazinyl amides of 18β-glycyrrhetinic acid

Dong Cai,
ZhiHua Zhang,
Yufan Meng,
KaiLi Zhu,
LiYi Chen,
ChangXiang Yu,
ChangWei Yu,
ZiYi Fu,
DianShen Yang and
YiXia Gong

Beilstein J. Org. Chem. 2020, 16, 798–808, doi:10.3762/bjoc.16.73

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Figure 1: Chemical structure of 18β-glycyrrhetinic acid and known derivatives.

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Scheme 1: Synthesis of compound 4. Reagents and conditions: (a) Ac₂O, NEt₃, DMF (cat.), DCM, 25 °C, 1 day; (b...

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Scheme 2: Synthesis of compound 4. Reagents and conditions: (a) Ac₂O, 130 °C, 1 h; (b) 1-Boc-piperazine, CH₃C...

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Figure 2: a) Estimated structure of the intermediate 6; b) Possible aminolysis process.

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Scheme 3: Synthesis of byproduct 11. Reagents and conditions: (a) chloroacetic anhydride, 130 °C, 1 h.

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Scheme 4: Synthesis of compound 17. Reagents and conditions: (a) chloroacetic anhydride, 130 °C, 1 h; (b) mor...

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Figure 3: Crystal structure of conpound 18.

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Published 21 Apr 2020

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